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Long non-coding RNA XIST regulates miR-106b-5p/P21 axis to suppress tumor progression in renal cell carcinoma

Author:
Sun, Ke, Jia, Zhankui, Duan, Ranran, Yan, Zechen, Jin, Zhibo, Yan, Liang, Li, Qi, Yang, Jinjian
Source:
Biochemical and biophysical research communications 2019 v.510 no.3 pp. 416-420
ISSN:
0006-291X
Subject:
carcinogenesis, cell proliferation, curcumin, microRNA, non-coding RNA, renal cell carcinoma, therapeutics, tissues
Abstract:
Long non-coding RNAs (lncRNAs) have been demonstrated to exert important roles in cancer development and progression. The biological function of lncRNA X-inactive specific transcript (XIST) in the development of renal cell carcinoma (RCC) and the underlying mechanisms are still largely unknown. In this study, we found that XIST was down-regulated in RCC tissues and cells. Overexpression of XIST significantly suppressed cell proliferation and induced cell G0/G1 arrest in vitro and inhibited tumor growth in vivo. We further found that XIST could directly interact with miR-106b-5p and increase the expression of P21. Thus, XIST positively regulated the expression of P21 through sponging miR-106b-5p, and played a tumor suppressor role in RCC. Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells. Our study exhibits the role of XIST as a miRNA sponge in RCC and supports the potential application of XIST in RCC therapy.
Agid:
6301081