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Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity

Author:
Huang, Shaomei, Gu, Jiangjiang, Ye, Jing, Fang, Bin, Wan, Shengfeng, Wang, Caoyu, Ashraf, Usama, Li, Qi, Wang, Xugang, Shao, Lin, Song, Yunfeng, Zheng, Xinsheng, Cao, Feifei, Cao, Shengbo
Source:
Journal of colloid and interface science 2019 v.542 pp. 198-206
ISSN:
0021-9797
Subject:
Flaviviridae, Ungulate protoparvovirus 1, antiviral agents, carbon quantum dots, death, encephalitis, pathogenicity, virion, viruses
Abstract:
Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections.
Agid:
6301178