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Benzoxazine monomer derived carbon dots as a broad-spectrum agent to block viral infectivity

Huang, Shaomei, Gu, Jiangjiang, Ye, Jing, Fang, Bin, Wan, Shengfeng, Wang, Caoyu, Ashraf, Usama, Li, Qi, Wang, Xugang, Shao, Lin, Song, Yunfeng, Zheng, Xinsheng, Cao, Feifei, Cao, Shengbo
Journal of colloid and interface science 2019 v.542 pp. 198-206
Flaviviridae, Ungulate protoparvovirus 1, antiviral agents, carbon quantum dots, death, encephalitis, pathogenicity, virion, viruses
Multiple viruses can cause infection and death of millions annually. Of these, flaviviruses are found to be highly prevalent in recent years with no distinctive antiviral therapies. Therefore, there is a desperate need for broad-spectrum antiviral drugs that can be active against a large number of existing and emerging viruses. Herein, we prepared a kind of benzoxazine monomer derived carbon dots (BZM-CDs) and demonstrated their infection-blocking ability against life-threatening flaviviruses (Japanese encephalitis, Zika, and dengue viruses) and non-enveloped viruses (porcine parvovirus and adenovirus-associated virus). It was found that BZM-CDs could directly bind to the surface of the virion, and eventually the first step of virus-cell interaction was impeded. The developed nanoparticles are active against both flaviviruses and non-enveloped viruses in vitro. Thus, the application of BZM-CDs may constitute an intriguing broad-spectrum approach to rein in viral infections.