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Cobalt(II)–catalyzed C8H alkoxylation of 1-naphthylamine derivatives with alcohols
- Zhang, Tingfang, Zhu, Hongmei, Yang, Fan, Wu, Yusheng, Wu, Yangjie
- Tetrahedron 2019 v.75 no.11 pp. 1541-1547
- alcohols, chemical reactions, cobalt, moieties, protocols, regioselectivity
- An efficient protocol for cobalt (II)-catalyzed regioselective aryl C8H bond alkoxylation of 1-naphthylamine derivatives with readily available alcohols has been developed, demonstrating an efficient approach to 8-alkoxy-1-naphthylamine derivatives with good functional group tolerance. Note that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective transformation.