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Inflammasome Inhibition Links IRGM to Innate Immunity

Author:
Nabar, Neel R., Kehrl, John H.
Source:
Molecular cell 2019 v.73 no.3 pp. 391-392
ISSN:
1097-2765
Subject:
inflammasomes, innate immunity, oligomerization, risk factors
Abstract:
IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al. (2019) report that IRGM limits NLRP3 inflammasome activation—by both direct inhibition of NLRP3/ASC oligomerization and selective autophagic destruction of NLRP3/ASC.
Agid:
6301895