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Long-term administration of protein hydrolysate from chicken feet induces antihypertensive effect and confers vasoprotective pattern in diet-induced hypertensive rats

Mas-Capdevila, Anna, Iglesias-Carres, Lisard, Arola-Arnal, Anna, Suarez, Manuel, Muguerza, Begoña, Bravo, Francisca I.
Journal of functional foods 2019 v.55 pp. 28-35
animal disease models, antihypertensive effect, body weight, cafeterias, chicken meat, diet, endothelial nitric oxide synthase, feet, gene expression regulation, glucose, glutathione, hypertension, lipids, nitric oxide, peptidyl-dipeptidase A, protein hydrolysates, rats, systolic blood pressure
The aim of this study was to evaluate the effect of long-term administration of the protein hydrolysate from chicken feet Hpp11 in diet-induced hypertensive rats. Rats were fed standard or cafeteria (CAF) diets for 12 weeks, and during the final 3 weeks, CAF animals were administered vehicle, Captopril or Hpp11. Systolic blood pressure (SBP) was recorded weekly. Body weight and plasmatic lipid and glucose levels were determined. Moreover, liver-reduced glutathione (GSH) levels, plasmatic angiotensin converting enzyme (ACE) activity and the endothelial gene expression of eNOS, KLF-2, Sirt-1, NOX4 and ET-1 were studied. A definite decrease in SBP was recorded in the rats that were administered Hpp11. Hpp11 downregulated gene expression of the vasoconstrictor ET-1 and induced the upregulation of NOX4 and NO enhancer Sirt-1, suggesting the vasoprotective effect of Hpp11. Moreover, Hp11 increased hepatic GSH. The present findings suggest that Hpp11 is a good candidate to ameliorate diet-induced hypertension.