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Quercetin dual interaction at the membrane level
- de Granada-FlorThese authors contributed equally., António, Sousa, Carla, Filipe, Hugo A. L., Santos, M. Soledade C. S., de Almeida, Rodrigo F. M.
- Chemical communications 2019 v.55 no.12 pp. 1750-1753
- chemical communication, chemical reactions, cholesterol, lipid bilayers, polyphenols, quercetin, sphingolipids
- Quercetin impact on lipid bilayers suggests a dual action mechanism at cell membranes. This widespread polyphenol displays high partition with low interference in the more fluid membrane domains, more vulnerable to oxidative attack, but strong perturbation of cholesterol/sphingolipid enriched domains, where signalling platforms are expected to assemble.