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Replication Timing Becomes Intertwined with 3D Genome Organization
- Ma, Jian, Duan, Zhijun
- Cell 2019 v.176 no.4 pp. 681-684
- DNA replication, genome, regulatory sequences, transcription (genetics)
- Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.