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Recent advances in the development of sesquiterpenoids in the treatment of type 2 diabetes

Author:
Chen, Lei, Lu, Xu, El-Seedi, Hesham, Teng, Hui
Source:
Trends in food science & technology 2019 v.88 pp. 46-56
ISSN:
0924-2244
Subject:
clearcutting, enzymes, food industry, glucose, herbs, hyperglycemia, insulin, islets of Langerhans, lipids, noninsulin-dependent diabetes mellitus, pathogenesis, pharmaceutical industry, sesquiterpenoids
Abstract:
Treatment of type 2 diabetes mellitus (T2DM) through dietary terpenoids is receiving a promising interest and sesquiterpenoids’ importance for food and pharmaceutical industries is mainly based on the existed scientific works.Sesquiterpenoids might contribute to prevent or delay T2DM by inhibiting key enzymes relevant for hyperglycemia, modulating β-cells function, targeting insulin signaling route, etc. Sesquiterpenoids also have been demonstrated to stimulate glucose uptake by enhancing glucose transport, repressing glucose production, or improving lipid metabolism.In this review, we summarized the latest developments of sesquiterpenoids in the treatment of type 2 diabetes as well as sesquiterpenoids-rich herbs against key enzymes relevant to hyperglycemia, and discussed their underlying molecular mechanisms of anti-diabetic potential. We also suggested a better evaluation of the pharmacological profile of sesquiterpenoids and their derivate with a clear-cut choice of possible human pathologies.
Agid:
6303986