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Determination of 23 perfluorinated alkylated substances in water and suspended particles by ultra-performance liquid chromatography/tandem mass spectrometry

Wang, X.F., Wang, Q., Li, Z.G., Huang, K., Li, L.D., Zhao, D.H.
Journal of environmental science and health 2018 v.53 no.14 pp. 1277-1283
acetonitrile, ammonium acetate, anion exchange, cleaning, detection limit, glass fibers, multiresidue analysis, nitrogen, solid phase extraction, soot, sorbents, standard deviation, tandem mass spectrometry, ultra-performance liquid chromatography
A practical multi-residue method based on ultra-performance liquid chromatography/tandem mass spectrometry was developed for the simultaneous determination of 23 perfluorinated alkylated substances (PFASs) in water and suspended particles. Suspended particle samples were extracted with 1% formic acid–acetonitrile and cleaned by matrix solid phase dispersion extraction using a C₁₈ sorbent and graphitized carbon black. Water samples were filtered through 0.7-μm glass fiber membranes and enriched utilizing weak anion exchange cartridges. The eluent was dried under a gentle stream of N₂ at 45°C and suspended in 1 mL acetonitrile–5 mM ammonium acetate (1:1, vol:vol). Gradient elution for chromatographic separation utilized acetonitrile and 5 mM ammonium acetate as mobile phases on a reverse phase C₁₈ column. The compounds were quantified using an internal standard method in multiple reaction-monitoring mode. Limits of detection and quantitation of the 23 PFAS test compounds in water samples were 0.5–10 ng L⁻¹ and 2–20 ng L–¹, respectively. Recoveries at three fortified levels of 20, 50, and 200 ng L–¹ ranged from 68.5% to 118% with relative standard deviations below 9.6%. We used this method to determine PFAS levels in real water and suspended particle samples and found high sensitivity and good reproducibility.