PubAg

Main content area

How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy

Author:
Ropert, Catherine
Source:
Cellular and molecular life sciences 2019 v.76 no.4 pp. 745-755
ISSN:
1420-682X
Subject:
Toll-like receptors, homeostasis, immune response, monocytes, pathogen-associated molecular patterns, pathogens, therapeutics, tissue repair
Abstract:
Toll-like receptors (TLR)s are central in immune response by recognizing pathogen-associated molecular patterns (PAMP)s. If they are essential to eliminate pathogens in earlier stages of infection, they also might play a role in homeostasis and tissue repair. TLR versatility parallels the plasticity of monocytes, which represent an heterogeneous population of immune cells. They are rapidly recruited to sites of infection and involved in clearance of pathogens and in tissue healing. This review underlines how TLRs have proved to be an interesting tool to study the properties of monocytes and why different therapeutic strategies exploring monocyte plasticity may be relevant in the context of chronic inflammatory disorders.
Agid:
6304735