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Short communication: Oral and intranasal administration of a modified-live Salmonella Dublin vaccine in dairy calves: Clinical efficacy and serologic response
- Cummings, Kevin J., Rodriguez-Rivera, Lorraine D., Capel, Michael B., Rankin, Shelley C., Nydam, Daryl V.
- Journal of dairy science 2019 v.102 no.4 pp. 3474-3479
- Holstein, Salmonella Dublin, antibody formation, dairy calves, dairy farming, enzyme-linked immunosorbent assay, field experimentation, intranasal administration, mortality, oral vaccination, pneumonia, risk, vaccines, weight gain, New York
- Our objectives were to evaluate the clinical efficacy of oral and intranasal administration of a commercial modified-live Salmonella Dublin vaccine in dairy calves and to determine the serologic response associated with these extralabel routes of administration. We conducted a randomized field trial with calves from a New York dairy farm following an outbreak of Salmonella Dublin. A total of 399 Holstein calves were allocated by pen to 3 treatment groups: oral vaccination, intranasal vaccination, and an unvaccinated control group. Administration of the vaccine through oral and intranasal routes did not have a significant effect on pneumonia incidence risk or weight gain; however, calves vaccinated orally and intranasally had lower mortality risk as compared with control calves. Among calves tested using a Salmonella Dublin ELISA, vaccination did not induce an increase in antibody production relative to control calves, indicating that oral and intranasal administration will not hinder diagnosis based on this assay.