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Pd-Catalyzed para-selective C–H difluoromethylation of aromatic carbonyls

Author:
Mao, Yang-Jie, Wang, Bing-Xin, Wu, Qiu-Zi, Zhou, Kun, Lou, Shao-Jie, Xu, Dan-Qian
Source:
Chemical communications 2019 v.55 no.14 pp. 2019-2022
ISSN:
1364-548X
Subject:
benzoates, bioactive compounds, catalytic activity, chemical communication, chemical reactions, ketones, moieties, palladium
Abstract:
A novel palladium catalyzed highly para-selective C–H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields. Moreover, the difuoromethylation was also compatible with several complex bioactive molecules.
Agid:
6308041