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Visualizing telomerase activity for tumour identification by hybridization-triggered ratiometric fluorescence

Author:
Zheng, Manli, Zhang, Ruilong, Tian, Xiaohe, Liu, Zhengjie, Zhang, Zhongping
Source:
Chemical communications 2019 v.55 no.14 pp. 2035-2038
ISSN:
1364-548X
Subject:
chemical communication, chemical compounds, chemical reactions, enzyme activity, fluorescence, neoplasm cells, neoplasms, telomerase, tissues
Abstract:
Telomerase is repressed stringently in normal cells but highly activated in tumours to maintain their uncontrollable growth. We report a ratiometric fluorescence strategy for visualising telomerase activity for tumour identification. Using our strategy, tumour cells and tissues can be differentiated from normal cells and tissues by the naked eye.
Agid:
6308042