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Destabilization of DNA through interstrand crosslinking by UO₂²⁺

Author:
Rossberg, André, Abe, Takaya, Okuwaki, Koji, Barkleit, Astrid, Fukuzawa, Kaori, Nakano, Tatsuya, Mochizuki, Yuji, Tsushima, Satoru
Source:
Chemical communications 2019 v.55 no.14 pp. 2015-2018
ISSN:
1364-548X
Subject:
DNA, chemical communication, chemical reactions, crosslinking, hydrogen bonding, nucleobases, phosphates, uranyl ions
Abstract:
UO₂²⁺ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO₂²⁺-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO₂²⁺ binding.
Agid:
6308043