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Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats

Author:
Sharma, Uma Kant, Kumar, Ramesh, Gupta, Ashutosh, Ganguly, Risha, Singh, Amit Kumar, Ojha, Anil Kumar, Pandey, Abhay Kumar
Source:
Food and chemical toxicology 2019 v.126 pp. 34-40
ISSN:
0278-6915
Subject:
albino, albumins, alkaline phosphatase, animal tissues, antioxidants, ascorbic acid, aspartate transaminase, azo dyes, bilirubin, blood serum, catalase, developing countries, eugenol, food additives, glutathione, kidneys, laboratory animals, liver, malondialdehyde, oral administration, oxidative stress, protein content, pyruvic acid, rats, renal function, superoxide dismutase, toxicity, toxicology, vitamin E, India
Abstract:
Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C. Oral administration of metanil yellow in albino Wistar rats for 28 days caused elevation in serum enzymes (glutamate oxaloacetate transaminase, gluatamate pyruvate transaminase, alkaline phosphatase), and total bilirubin along with decline in albumin and total protein levels. At tissue level, activities of oxidative stress markers viz., superoxide dismutase, catalase and reduced glutathione in liver and kidney were reduced to about half while malondialdehyde level increased significantly under the influence of metanil yellow. Co-administration of eugenol/vitamin E/vitamin C in metanil yellow intoxicated rats exhibited considerable restoration of oxidative stress as well as hepatic and renal function markers in serum and tissues. The study revealed that eugenol has antioxidant, hepatoprotective and renoprotective activities.
Agid:
6309565