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Serum Bisphenol A concentrations in men with idiopathic infertility
- Mantzouki, Christina, Bliatka, Despoina, Iliadou, Paschalia K., Margeli, Alexandra, Papassotiriou, Ioannis, Mastorakos, George, Kousta, Eleni, Goulis, Dimitrios G.
- Food and chemical toxicology 2019 v.125 pp. 562-565
- bisphenol A, blood serum, cryptorchidism, male fertility, males, men, toxicology
- Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed BPA according to the cause of male infertility.To investigate serum BPA concentrations in infertile men according to infertility cause.Men with infertility (n = 55) [non-obstructive azoospermia (n = 23), cryptorchidism (n = 12), varicocele (n = 20)] compared with fertile men (n = 25). Serum BPA concentrations were measured along with clinical and hormonal assessment.BPA was detected in all men, with no difference between infertile and control groups [median (IQR) 0.19 (0.45) vs. 0.18 (0.28) ng/ml, p = 0.689] or among the infertility cause [azoospermia 0.30 (0.69), cryptorchidism 0.12 (0.39), varicocele 0.17 (0.23) ng/ml, p = 0.316]. High concentrations of BPA (>3 ng/ml) were observed only in infertile men. Α negative correlation was observed between ΒΡΑ concentrations and AMH (r = −0.320, p < 0.01).Although male infertility cannot be attributed to exposure to BPA, high concentrations of BPA could contribute to infertility.