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Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

Author:
HeThese authors contributed equally to this work., Liangcan, Pang, Kanglei, Liu, Wenwen, Tian, Yue, Chang, Lin, Liu, Xu, Zhao, Meiting, Liu, Yong, Li, Yantao, Jiang, Xingyu, Song, Rui, Liu, Yaling
Source:
Journal of materials chemistry B 2019 v.7 no.7 pp. 1050-1055
ISSN:
2050-7518
Subject:
chemistry, doxorubicin, human cell lines, irradiation, nanocarriers, neoplasms
Abstract:
Core–shell Au@zeolitic-imidazolate-framework-8 (ZIF-8) nanostructures are reported as a nanocarrier with both a high drug payload and high cancer treatment efficiency in vitro. Impressively, when used as multifunctional drug delivery vehicles, such core–shell Au@ZIF-8 nanostructures not only exhibit light- and pH-controlled drug release properties, but also provide two synergetic therapeutic modes for cancer treatment, resulting in 98% cell-killing activity after 30 min light irradiation followed by 24 h incubation even though HeLa cells are treated only by Au@ZIF-8 nanostructures loaded with 10 μM doxorubicin hydrochloride. All these results demonstrate the promising applications of this type of core–shell nanostructure in biomedical fields.
Agid:
6309918