Jump to Main Content
Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro
- HeThese authors contributed equally to this work., Liangcan, Pang, Kanglei, Liu, Wenwen, Tian, Yue, Chang, Lin, Liu, Xu, Zhao, Meiting, Liu, Yong, Li, Yantao, Jiang, Xingyu, Song, Rui, Liu, Yaling
- Journal of materials chemistry B 2019 v.7 no.7 pp. 1050-1055
- chemistry, doxorubicin, human cell lines, irradiation, nanocarriers, neoplasms
- Core–shell Au@zeolitic-imidazolate-framework-8 (ZIF-8) nanostructures are reported as a nanocarrier with both a high drug payload and high cancer treatment efficiency in vitro. Impressively, when used as multifunctional drug delivery vehicles, such core–shell Au@ZIF-8 nanostructures not only exhibit light- and pH-controlled drug release properties, but also provide two synergetic therapeutic modes for cancer treatment, resulting in 98% cell-killing activity after 30 min light irradiation followed by 24 h incubation even though HeLa cells are treated only by Au@ZIF-8 nanostructures loaded with 10 μM doxorubicin hydrochloride. All these results demonstrate the promising applications of this type of core–shell nanostructure in biomedical fields.