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Aromatization-Driven Cascade [1,5]-Hydride Transfer/Spirocyclization Promoted by Fluorinated Alcohols
- Lv, Xintong, Hu, Fangzhi, Duan, Kang, Li, Shuai-Shuai, Liu, Qing, Xiao, Jian
- Journal of organic chemistry 2019 v.84 no.4 pp. 1833-1844
- ambient temperature, hydrolysis, moieties, organic chemistry, quinones
- The aromatization-driven redox-neutral cascade [1,5]-hydride transfer/spirocyclization and cascade [1,5]-hydride transfer/hydrolysis from para-quinone methide in HFIP were developed. These protocols enabled the synthesis of azaspirocyclohexadienones and ortho-benzylated anilines in good to high yields under mild conditions, featuring room temperature, additive-free, and good functional group tolerance.