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Rhodium-catalyzed aminohydroxylation of unactivated alkenes in aqueous media for the benign synthesis of 1,2-amino alcohols

Author:
Shi, Yufeng, Wang, Yufan, Lu, Xunbo, Zhang, Yulong, Wu, Yuzhou, Zhong, Fangrui
Source:
Green chemistry 2019 v.21 no.4 pp. 780-784
ISSN:
1463-9270
Subject:
Bronsted acids, Lewis bases, alkenes, amino alcohols, catalysts, green chemistry
Abstract:
An efficient catalytic aminohydroxylation reaction of alkenes in aqueous media is disclosed for the first time. The multiple roles water plays as a reaction medium, nucleophile, and Brønsted acid catalyst provide high reactivity and chemo- and regioselectivities to this transformation. This method provides easy access to various valuable vicinal amino alcohols in a sustainable manner.
Agid:
6311253