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A guide to microRNA‐mediated gene silencing

Author:
Quévillon Huberdeau, Miguel, Simard, Martin J.
Source:
TheFEBS journal 2019 v.286 no.4 pp. 642-652
ISSN:
1742-464X
Subject:
eukaryotic cells, gene silencing, genes, microRNA
Abstract:
As an important regulator of gene expression in eukaryotes, microRNAs (miRNAs) have been subject to extensive research to understand their pleiotropic roles in development and pathological processes. Here, we review strategies that have been developed to map microRNA‐target interactions and the most effective methods to attribute post‐transcriptional gene regulation through miRNA‐mediated silencing. We further discuss the importance of the biological context for silencing.
Agid:
6311618