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Ethical considerations of cellular immunotherapy for cancer
- Ren, Sang-sang, Deng, Jing-wen, Hong, Meng, Ren, Yan-li, Fu, Hai-jing, Liu, Yan-ning, Chen, Zhi
- Journal of Zhejiang University 2019 v.20 no.1 pp. 23-31
- T-lymphocytes, dendritic cells, ethics, high-throughput nucleotide sequencing, immunology, immunotherapy, molecular biology, natural killer cells, neoplasms, patients, China
- With the rapid development of immunology, molecular biology, and associated technologies such as next-generation sequencing, cellular immunotherapy has recently become the fourth major cancer treatment. Immunotherapies based on T cells, natural killer cells, and dendritic cells play key roles in cancer immunotherapy. However, their application in clinical practice raises several ethical issues. Thus, studies should focus on proper adherence to basic ethical principles that can effectively guide and solve related clinical problems in the course of treatment, improve treatment effects, and protect the rights and interests of patients. In this review, we discuss cellular immunotherapy-related ethical issues and highlight the ethical practices and current status of cellular immunotherapy in China. These considerations may supplement existing ethical standards in cancer immunotherapy.