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Is Fat Mass Cross-Sectionally Associated with Cortical Aβ Load in the Human Brain?

Maltais, Mathieu, de Souto Barreto, P., Rolland, Y., Vellas, B.
The journal of nutrition, health & aging 2019 v.23 no.2 pp. 207-210
amyloid, apolipoprotein E, body mass index, brain, dementia, dual-energy X-ray absorptiometry, education, elderly, muscles, positron-emission tomography
OBJECTIVES: The objective of this study was to examine the relationship of fat mass (FM) with brain amyloid (Aβ) load in older adults. METHODS: Data from the Multidomain Alzheimer’s Preventive Trial (MAPT) for Positron emission tomography and dual-energy X-ray absorptiometry (DXA) were used. Linear regressions controlling for appendicular muscle, age, education, clinical dementia rating scale and Apolipoprotein-E were performed to explore the relationships between FM, trunk FM and Aβ-load. RESULTS: Thirty-nine participants (75.7 ± 4.2 years old) with an average BMI of 27.5 ± 4.0 kg/m2 were analyzed in this study. There were significant and positive associations of both total and trunk FM with Aβ load [0.01 (0.002-0.02) and 0.02 (0.001-0.04), respectively]; however, when adding ApoE-ε4 as a confounder, associations were no longer significant. CONCLUSIONS: This study has found associations between FM as measured by DXA and cerebral Aβ load, suggesting that excessive FM might be involved in AD pathology.