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The Association Between Sarcopenia and Prealbumin Levels Among Elderly Chinese Inpatients

Chen, Q., Hao, Q., Ding, Y., Dong, Birong
The journal of nutrition, health & aging 2019 v.23 no.2 pp. 122-127
body mass index, confidence interval, cross-sectional studies, elderly, gait, hospitals, men, muscle strength, muscles, patients, physical activity, prealbumin, regression analysis, sarcopenia, women, China
OBJECTIVES: The goal of the present study was to assess the relationship between sarcopenia and prealbumin levels among hospitalized patients ages 60 and older. DESIGN: Cross-sectional study. SETTING: The geriatric wards in Guizhou Provincial People’s Hospital, Guiyang. Guizhou, China. MEASUREMENTS: Sarcopenia was defined according to the Asian Working Group for Sarcopenia (AWGS) criteria, which consist of three components: low muscle mass, assessed based on an index of appendicular skeletal mass/height2 <7.0kg/m² for men and <5.4kg/m² for women; low muscle strength, defined as handgrip strength <26kg for men and <18kg for women; and low physical performance, defined as gait speed <0.8m/s. Using these criteria, sarcopenia was defined as presence of low muscle mass in addition to low muscle strength and/or low physical performance. Prealbumin levels and other variables were considered as being independent variables in an effort to evaluate any potential associations between these factors and sarcopenia status using non-adjusted and multivariateadjusted regression models. RESULTS: The overall prevalence of sarcopenia was 60.17%, affecting 65 (70.65%) men and 6 (23.08%) women in the present study. Age, body mass index (BMI), and prealbumin levels were each independently associated with sarcopenia (p<0.05). In a multivariate model, after adjusting for all potential covariates, prealbumin levels remained significantly associated with sarcopenia incidence, with an inflection point of 265.9mg/L. The effect sizes and the confidence intervals on the left and right sides of this inflection point were 0.94 (0.90 to 0.99) and 1.07 (0.93 to 1.23), respectively. CONCLUSION: Among older Chinese inpatients in the present study, prealbumin levels were negatively correlated with sarcopenia incidence, when prealbumin levels were below 265.9mg/L.