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Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells

Author:
Cheng, Qian, Teng, Kun-Xu, Ding, Yuan-Fu, Yue, Ludan, Yang, Qing-Zheng, Wang, Ruibing
Source:
Chemical communications 2019 v.55 no.16 pp. 2340-2343
ISSN:
1364-548X
Subject:
aromatic hydrocarbons, chemical reactions, drugs, emulsions, glutathione, lung neoplasms, nanoparticles, neoplasm cells, spermine
Abstract:
Paclitaxel-loaded nanoparticles based on a bispillar[5]arene compound were successfully developed using a microemulsion method for the first time. The nanoparticles exhibited dual stimuli-responsiveness towards both spermine and glutathione, allowing precisely selective drug release in lung cancer cells that overexpress both stimuli.
Agid:
6312518