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Dual stimuli-responsive bispillararene-based nanoparticles for precisely selective drug delivery in cancer cells
- Cheng, Qian, Teng, Kun-Xu, Ding, Yuan-Fu, Yue, Ludan, Yang, Qing-Zheng, Wang, Ruibing
- Chemical communications 2019 v.55 no.16 pp. 2340-2343
- aromatic hydrocarbons, chemical reactions, drugs, emulsions, glutathione, lung neoplasms, nanoparticles, neoplasm cells, spermine
- Paclitaxel-loaded nanoparticles based on a bispillararene compound were successfully developed using a microemulsion method for the first time. The nanoparticles exhibited dual stimuli-responsiveness towards both spermine and glutathione, allowing precisely selective drug release in lung cancer cells that overexpress both stimuli.