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Photoactive chelates for radiolabelling proteins

Author:
Eichenberger, Larissa S., PatraPresent address: Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India., Malay, Holland, Jason P.
Source:
Chemical communications 2019 v.55 no.16 pp. 2257-2260
ISSN:
1364-548X
Subject:
antibodies, chelates, immunoglobulins, peptides, photochemical reactions, radiolabeling, synthesis
Abstract:
Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, ⁶⁸Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.
Agid:
6312519