Jump to Main Content
Photoactive chelates for radiolabelling proteins
- Eichenberger, Larissa S., PatraPresent address: Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India., Malay, Holland, Jason P.
- Chemical communications 2019 v.55 no.16 pp. 2257-2260
- antibodies, chelates, immunoglobulins, peptides, photochemical reactions, radiolabeling, synthesis
- Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, ⁶⁸Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.