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Catalyst-controlled cascade synthesis of bridged bicyclic tetrahydrobenz[b]azepine-4-ones
- Kroc, Michelle A., Markiewicz, Maciej, Pace, Wiktoria H., Wink, Donald J., Anderson, Laura L.
- Chemical communications 2019 v.55 no.16 pp. 2309-2312
- chemical reactions, chemical structure, heterocyclic compounds, synthesis
- A catalyst-controlled cascade reaction has been developed for the synthesis of bridged bicyclic tetrahydrobenz[b]azepin-4-ones from N-arylnitrones and allenes. This method expands the accessible structural diversity of a synthetically challenging heterocyclic scaffold and tunes a catalyst-sensitive process in a new direction.