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An efficient one pot three-component synthesis of 2,4,6-triarylpyridines using triflimide as a metal-free catalyst under solvent-free conditions

Author:
Wang, Hongshe, Zhao, Weixing, Du, Juan, Wei, Fenyan, Chen, Qi, Wang, Xiaomei
Source:
RSC advances 2019 v.9 no.9 pp. 5158-5163
ISSN:
2046-2069
Subject:
Bronsted acids, acetophenones, aldehydes, ammonium acetate, catalysts, pyridines
Abstract:
A simple and efficient protocol developed for one pot three-component synthesis of 2,4,6-triarylpyridines from aromatic aldehydes, substituted acetophenones and ammonium acetate using the versatile super Brønsted acid triflimide (HNTf₂) as an effective catalyst is described. The reactions proceed well in the presence of 1 mol% of HNTf₂ at 80 °C under solvent-free conditions and provide the corresponding triarylpyridines in good to excellent yields. The method reported has several advantages such as a metal-free and commercially available catalyst, mild reaction conditions and lower loading of catalyst.
Agid:
6312745