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2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis
- Wood, James M., Furkert, Daniel P., Brimble, Margaret A.
- Natural product reports 2019 v.36 no.2 pp. 289-306
- amines, antioxidant activity, immunostimulants, secondary metabolites, sugars
- Covering: up to April 2018 2-Formylpyrroles are ubiquitous in nature, arising from the non-enzymatic Maillard reactions of amines and sugars. Often confused for secondary metabolites, these Maillard products display interesting biological activities including hepatoprotective, immunostimulatory, antiproliferative and antioxidant effects. This review presents all 2-formylpyrrole natural products reported to date and identifies structural sub-classes for their categorisation. The origin, biological activity and chemical syntheses of these natural products are discussed herein.