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Physical nanochitin/microemulsion composite hydrogels for hydrophobic Nile Red release under in vitro physiological conditions
- Wang, Zhiguo, Wang, Rong, Xu, Pengbo, Yu, Juan, Liu, Liang, Fan, Yimin
- Cellulose 2019 v.26 no.2 pp. 1221-1230
- cellulose, coagulation, composting, drugs, dyes, emulsions, gases, hydrogels, hydrophobicity, pH, temperature
- A physical composite nanochitin/microemulsion (NCh/ME) hydrogel for a prolonged release of hydrophobic compounds (drugs) under in vitro physiological conditions was investigated. A strong physical hydrogel was prepared by an alkali gas phase coagulation bath composting NCh with an oil in water ME in which a hydrophobic dye, Nile Red (NR), was embedded to simulate a drug release process. Different release conditions, such as concentration of NCh, diameter of ME, temperature and specific surface areas, were studied. The results showed that the NCh/ME composite hydrogel effectively encapsulated NR with a prolonged release period of 60 h in phosphate-buffered saline (PBS pH 7.4, similar to physiological conditions), which demonstrated the significance of NCh/ME composite hydrogels for hydrophobic compound (drug) delivery.