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A rapid and highly selective paper-based device for high-throughput detection of cysteine with red fluorescence emission and a large Stokes shift

Author:
Zhou, Jia, Yu, Changmin, Li, Zheng, Peng, Pingping, Zhang, Duoteng, Han, Xun, Tang, Hezhou, Wu, Qiong, Li, Lin, Huang, Wei
Source:
Analytical methods 2019 v.11 no.10 pp. 1312-1316
ISSN:
1759-9679
Subject:
analytical methods, chemical species, cysteine, fluorescence, fluorescent dyes, point-of-care testing
Abstract:
A paper-based device is a promising technology for point-of-care testing (POCT). In this work, a novel fluorescent probe with red emission (650 nm) and a large Stokes shift (∼170 nm) for Cys detection was reported for the first time. This probe exhibited a highly selective and rapid response to Cys within 5 min. Importantly, by introducing this probe into microfluidic paper-based analytical devices (μPADs), a paper-based device was developed for simple, high-throughput and highly sensitive detection of Cys. Finally, satisfactory performance of this paper-based device for Cys detection was achieved in real samples, which indicates the great potential of our strategy in the construction of POCT systems for detecting analytes.
Agid:
6315731