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Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo

Author:
Yang, Xinglong, Wei, Qin, Shao, Huawu, Jiang, Xingyu
Source:
ACS applied materials & interfaces 2019 v.11 no.8 pp. 7725-7730
ISSN:
1944-8252
Subject:
antibiotics, bacteria, bacterial infections, biofilm, drugs, erythrocytes, glucosamine, mice, multiple drug resistance, nanogold, tissue repair, viability
Abstract:
Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using d-glucosamine (GluN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.
Agid:
6315796