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Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines

Author:
Jung, Heesun, Kang, Yoon Young, Mok, Hyejung
Source:
Biomaterials science 2019 v.7 no.3 pp. 856-859
ISSN:
2047-4849
Subject:
biocompatible materials, calcium chloride, cytokines, hemostasis, membrane proteins, sonication, thrombin
Abstract:
Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without a notable release of pro-inflammatory cytokines. These natural and biocompatible platelet-derived nanovesicles have great potential as biomaterials for inflammation-free injectable hemostasis.
Agid:
6316244