Jump to Main Content
Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines
- Jung, Heesun, Kang, Yoon Young, Mok, Hyejung
- Biomaterials science 2019 v.7 no.3 pp. 856-859
- biocompatible materials, calcium chloride, cytokines, hemostasis, membrane proteins, sonication, thrombin
- Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without a notable release of pro-inflammatory cytokines. These natural and biocompatible platelet-derived nanovesicles have great potential as biomaterials for inflammation-free injectable hemostasis.