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Application of molecularly imprinted polymer nanoparticles for degradation of the bacterial autoinducer N-hexanoyl homoserine lactone

Author:
Garcia Lopez, J., Piletska, E. V., Whitcombe, M. J., Czulak, J., Piletsky, S. A.
Source:
Chemical communications 2019 v.55 no.18 pp. 2664-2667
ISSN:
1364-548X
Subject:
homoserine, hydrolysis, molecular imprinting, nanoparticles, polymers, quorum sensing
Abstract:
A novel bacterial quorum quenching system is presented. For the first time the degradation of N-l-hexanoyl homoserine lactone (C6-AHL), a Gram-negative quorum sensing autoinducer, has been enhanced using molecularly imprinted nanoparticles (MIP NPs) which were prepared using transition state analogue of the γ-lactone ring hydrolysis as template.
Agid:
6316250