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Efficient synthesis of carbon-11 labelled acylsulfonamides using [¹¹C]CO carbonylation chemistry

Author:
van der Wildt, Berend, Shen, Bin, Chin, Frederick T.
Source:
Chemical communications 2019 v.55 no.21 pp. 3124-3127
ISSN:
1364-548X
Subject:
cross-coupling reactions, drugs, models, organic halogen compounds, sulfonamides
Abstract:
Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [¹¹C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.
Agid:
6316277