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Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis

Author:
JeongCurrent address: Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Sinyoung, KangCurrent address: Gordon Center for Medical Imaging, Department of Radiology, Boston, MA 02114, USA., Homan, Cha, Myeong Geun, Lee, Sung Gun, Kim, Jaehi, Chang, Hyejin, Lee, Yoon-Sik, Jeong, Dae Hong
Source:
Chemical communications 2019 v.55 no.18 pp. 2700-2703
ISSN:
1364-548X
Subject:
Raman spectroscopy, amino acids, bioassays, chemical compounds, chemical reactions, screening
Abstract:
We developed a ready-to-read on-bead peptide encoding method for high-throughput screening bioassays. With two-dimensional surface-enhanced Raman scattering nano-identifiers (2D-SERS IDs) which are concurrently labelled with two SERS codes (coupling steps and kinds of amino acid), we could possibly generate more than 10 trillion codes with only 30 Raman label compounds.
Agid:
6316310