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Four-component thiazole formation from simple chemicals under metal-free conditions
- Jiang, Jingjing, Huang, Huawen, Deng, Guo-Jun
- Green chemistry 2019 v.21 no.5 pp. 986-990
- aldehydes, ammonium salts, green chemistry, ketones, sulfur, thiazoles
- Multi-component reactions for the synthesis of polysubstituted thiazoles from simple chemicals are described. Under metal-free reaction conditions, cheap and easily available ketones, aldehydes, ammonium salt, and elemental sulfur are self-assembled to provide entries to three thiazoles in moderate to good yield with a range of functionalities tolerated.