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Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Author:
Ma, Ying, Tian, Haigang, Jin, Zhengyu, Li, Xiaoyong, Li, Yiping
Source:
RSC advances 2019 v.9 no.12 pp. 6510-6514
ISSN:
2046-2069
Subject:
acetaminophen, fluorescent dyes, liver, mice, monitoring, overdose
Abstract:
A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO⁻) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO⁻ in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO⁻in vivo.
Agid:
6316374