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SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish
- Zhao, Lei, Tan, Jiaqi, Li, Dan, Jiang, Lijun, Li, Tongjuan, Yang, Yi, Wang, Gaoxiang, Shang, Zhen, Wang, Jue, Zhou, Jianfeng
- Biochemical and biophysical research communications 2019 v.511 no.4 pp. 896-902
- Danio rerio, T-lymphocytes, apoptosis, caspases, gastrulation, homeostasis, humans, immune response, mutants, zinc
- Zinc (Zn) is an essential trace element that modulate innate and acquired immune responses, and its deficiency triggers lymphopenia. However, the precise mechanisms underlying zinc-mediated lymphocyte maintenance have not been well clarified. Here, we have successfully generated a zip6-null mutant zebrafish line using TALENs. The Zip6-null mutant zebrafish developed normally during gastrulation. Loss of zip6 in zebrafish resulted in significant T lymphocyte reduction and a decrease in intracellular Zn levels. And the zip6 deficiency increases caspase-related cell apoptosis in both zebrafish cells and human T cells. Our results suggest that ZIP6 plays a critical part in T cell development, and enhance our understanding of Zn homeostasis and immune system maintenance.