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Bead-type polystyrene/nano-CaCO₃ (PS/nCaCO₃) composite: a high-performance adsorbent for the removal of interleukin-6

Author:
ChaiThese authors contributed equally to this work., Yamin, Chen, Jie, Wang, Tingting, Chen, Jian, Ma, Yingda, Cheng, Guanghui, Li, Chunran, Zhang, Qian, Ou, Lailiang, Li, Wenzhong
Source:
Journal of materials chemistry B 2019 v.7 no.9 pp. 1404-1414
ISSN:
2050-7518
Subject:
adsorbents, adsorption, autoimmune diseases, biocompatibility, blood, clinical trials, humans, interleukin-6, models, nanocomposites, patients, polymerization, polystyrenes, porosity, sorption isotherms, strength (mechanics), surface area
Abstract:
A novel nano-CaCO₃ (nCaCO₃) particle composite-derived polystyrene (PS) resin was successfully synthesized by a suspension polymerization method. The nCaCO₃ reinforced PS material (PS/nCaCO₃) possessed a structure with abundant mesopores of high porosity, high specific surface area (828.3 m² g⁻¹) and large pore volume (1.83 cm³ g⁻¹). It was revealed that the incorporation of nCaCO₃ into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. The adsorption isotherm could be described by the Langmuir model and classified as S-3 type, showing an IL-6 uptake of up to 25.6 ng g⁻¹ at an equilibrium concentration of about 500 ng L⁻¹. The adsorption capacity for IL-6 of PS/nCaCO₃ is not only significantly higher than that of PS (without nCaCO₃), but also superior to those of currently available adsorbents that are under clinical studies (e.g., CytoSorb™ towards cytokines). In addition, the PS/nCaCO₃ adsorbent also had good hemocompatibility and showed no leakage of nCaCO₃ in the plasma in a flowing model system. Therefore, the synthesized PS/nCaCO₃ nano-composite has a great potential to be used as an efficient adsorbent for the removal of interleukin-6 (IL-6) from blood of inflammatory and auto-immune disease patients through hemoperfusion.
Agid:
6322464