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Dinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction of N-Boc Imines and Nitroalkanes under Ambient Conditions

Author:
Liu, Shanshan, Gao, Wen-Chao, Miao, Yu-Hang, Wang, Min-Can
Source:
Journal of organic chemistry 2019 v.84 no.5 pp. 2652-2659
ISSN:
1520-6904
Subject:
catalysts, chemical reactions, chemical structure, enantioselectivity, imines, nitroalkanes, organic chemistry
Abstract:
The asymmetric aza-Henry reaction of N-Boc imines and nitroalkanes was realized in the presence of 10 mol % dinuclear zinc-AzePhenol catalysts under ambient conditions. A variety of nitroamines were obtained in good yields (up to 97%) with excellent enantioselectivities (up to 99% ee) and high diasteroselectivity (up to 14:1 dr). Our protocol combined the operational simplicity and mild reaction conditions, thus making the process amenable for technical applications.
Agid:
6323044