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Synthesis of Amino-Substituted α- and δ-Carbolines via Metal-Free [2 + 2 + 2] Cycloaddition of Functionalized Alkyne-Nitriles with Ynamides
- Zhang, Jingyi, Guo, Meichao, Chen, Yajuan, Zhang, Shuangshuang, Wang, Xiao-Na, Chang, Junbiao
- Organic letters 2019 v.21 no.5 pp. 1331-1336
- cycloaddition reactions, moieties, organic compounds, regioselectivity
- A metal-free [2 + 2 + 2] cycloaddition of alkyne-cyanamides or ynamide-nitriles with ynamides is described for the efficient synthesis of amino-substituted α- and δ-carbolines. This novel methodology is environmentally friendly and allows for highly regioselective access to carboline derivatives in good to excellent yields with wide functional group tolerance.