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Myths, reality and future of mesenchymal stem cell therapy

Author:
Poltavtseva, R. A., Poltavtsev, A. V., Lutsenko, G. V., Svirshchevskaya, E. V.
Source:
Cell and tissue research 2019 v.375 no.3 pp. 563-574
ISSN:
0302-766X
Subject:
inflammation, medicinal properties, mesenchymal stromal cells, therapeutics, tissue repair
Abstract:
Mesenchymal stem cell (MSC) therapy represents an alternative approach for tissue regeneration and inflammation control. In spite of a huge amount of preclinical data that has been accumulated on the therapeutic properties of MSCs, there are many conflicting results, possibly due to differences in the properties of MSCs obtained from different sources or underestimated mechanisms of MSC in vivo behavior. This review consolidates the in vivo effects of MSC therapy, discusses the fate of MSCs after intravascular and local delivery and proposes possible trends in MSC therapy.
Agid:
6324657