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Genomewide association study for C-reactive protein in Indians replicates known associations of common variants
- Prasad, Gauri, Giri, Anil K., Basu, Analabha, Tandon, Nikhil, Bharadwaj, Dwaipayan
- Journal of genetics 2019 v.98 no.1 pp. 20
- C-reactive protein, biomarkers, genes, genetic factors, inflammation, loci, metabolic diseases, transcription factors, India
- Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-[Formula: see text] gene (HNF1A) were identified among Indian subjects. We also detected prior associations of several variants in/near metabolic and inflammatory process genes: APOC1, LEPR, CRP, HNF4A, IL6R and APOE with modest associations. This study confirms that Indians from Indo-European origin display similar core universal genetic factors for CRP levels.