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A new selaginellin derivative and a new triarylbenzophenone analog from the whole plant of Selaginella pulvinata

Author:
Liu, Xin, Tang, Gui-Hua, Weng, Han-Zhuang, Zhang, Jun-Sheng, Xu, You-Kai, Yin, Sheng
Source:
Journal of Asian natural products research 2018 v.20 no.12 pp. 1123-1128
ISSN:
1477-2213
Subject:
Selaginella pulvinata, inhibitory concentration 50, nuclear magnetic resonance spectroscopy, screening
Abstract:
Five selaginellin derivatives (1 and 3–6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1−6 exhibited potent activities with the IC₅₀ values in the range of 1.04−9.35 μM.
Agid:
6326125