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A new single-stage method for obtaining of betulin phenylcarbamates

Author:
Mamaeva, A. Elena, Kaliyeva, S. Saltanat, Bakibaev, A. Abdigali, Tashenov, K. Auezkhan, Nurpeiis, E. Yenglik
Source:
Journal of Asian natural products research 2018 v.20 no.12 pp. 1162-1166
ISSN:
1477-2213
Subject:
betulin, bioactive compounds, chemoselectivity, moieties
Abstract:
A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives – phenylcarbamates are valuable as bioactive substances.
Agid:
6326127