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Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats

Author:
Wu, Wen-Yu, Zhong, Yue, Lu, Yu-Ting, Sun, Ying, Li, Nian-Guang, Shi, Zhi-Hao, Dong, Ze-Xi, Gu, Ting, Xue, Xin, Fang, Fang, Li, He-Min, Tang, Yu-Ping, Duan, Jin-Ao
Source:
Journal of Asian natural products research 2018 v.20 no.12 pp. 1167-1181
ISSN:
1477-2213
Subject:
ischemia, metabolites, neurons, protective effect, rats
Abstract:
Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia.
Agid:
6326128