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Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18
- Zhou, Yue, Li, Yun-Hai, Yu, Hao-Bing, Liu, Xiao-Yu, Lu, Xiao-Ling, Jiao, Bing-Hua
- Journal of Asian natural products research 2018 v.20 no.12 pp. 1108-1115
- Penicillium, fungi, inhibitory concentration 50, nuclear magnetic resonance spectroscopy, protein-tyrosine-phosphatase, secondary metabolites, sesquiterpenoids, spectral analysis, Antarctic region
- A new furanone derivative, butanolide A (1), and a new sesquiterpene, guignarderemophilane F (2), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher’s method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound 1 showed moderate inhibitory activity against PTP1B with IC₅₀ value of 27.4 μM.