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Two new secolignans from the roots of Urtica fissa

Author:
Lu, Xuan, Li, Xue-Qing, Qin, Hai-Hong, Feng, Bao-Min, Cheng, Xing-Hua, Yang, Qing-Xiong, Yu, Da-Yong, Shi, Li-Ying, Yu, Zong-Xia, Fang, Xue-Xun
Source:
Journal of Asian natural products research 2019 v.21 no.2 pp. 165-170
ISSN:
1477-2213
Subject:
Urtica, enzymes, nuclear magnetic resonance spectroscopy, roots
Abstract:
Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxy-3- methoxyphenyl)methyl]butyrolactone (1) and 3,4-trans-3-hydroxymethyl-4- [bis(3,4-dimethoxyphenyl)methyl]butyrolactone (2) have been isolated from the roots of Urtica fissa E.Pritz. Their structures were determined on the basis of spectroscopic methods, especially ¹H NMR, ¹³C NMR, 2D NMR, and HR-ESI-MS. The inhibitory effects on N1 and N2, two subtypes of neuraminidases (NAs), of these two compounds were assayed.
Agid:
6326142