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N-containing compounds from Periplaneta americana and their activities against wound healing
- Yan, Yong-Ming, Xiang, Bin, Zhu, Hong-Jie, Qi, Jing-Jing, Hou, Bo, Geng, Fu-Neng, Cheng, Yong-Xian
- Journal of Asian natural products research 2019 v.21 no.2 pp. 93-102
- Periplaneta americana, angiogenesis, bioactive properties, cell movement, cell proliferation, computational methodology, medicinal insects, nitric oxide, pyrazines, spectroscopy, tissue repair
- Three new compounds, periplanamides A (1) and B (2), periplanpyrazine A (3), a new naturally occurring compound salicyluric acid methyl ester (6), and seventeen known compounds were isolated from the medicinal insect Periplaneta americana. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The absolute configurations of 2 were assigned by computational methods. Biological activities of these isolates except 1, 9, 11, and 13 toward nitric oxide (NO) production, cell proliferation in HDFs, cell migration and angiogenesis in HUVECs were evaluated.