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Discovery of Populusone, a Skeletal Stimulator of Umbilical Cord Mesenchymal Stem Cells from Populus euphratica Exudates
- Liu, Kai-Xin, Zhu, Yan-Xia, Yan, Yong-Ming, Zeng, Yue, Jiao, Ya-Bin, Qin, Fu-Ying, Liu, Jia-Wang, Zhang, Yuan-Yuan, Cheng, Yong-Xian
- Organic letters 2019 v.21 no.6 pp. 1837-1840
- Populus euphratica, X-ray diffraction, biosynthesis, carbon, chemical reactions, chemical structure, keratinocytes, mesenchymal stromal cells, organic compounds, spectroscopy, umbilical cord
- Populusone (1), a cembrane-type macrocyclic trinorditerpenoid, was isolated from the exudates of Populus euphratica and shown to have an unprecedented carbon skeleton, The structure was identified using spectroscopic methods and X-ray crystallography. A possible pathway for the biosynthesis of 1 was proposed. Populusone (10 μM) was found to promote proliferation and differentiation of umbilical cord derived mesenchymal stem cells into keratinocyte like cells.